Nolvadex Post Cycle Therapy

Nolvadex Post Cycle Thearpy

Nolvadex Properties and history

Nolvadex is one of the Selective Estrogen receptor modulators (SERMs) family of drugs. SERMs are part of the larger family of drugs called anti-estrogens. The other subdivision of drugs that fall under the anti-estrogens class is called the aromatase inhibitors (AIs) and includes drugs like Arimidex (Anastrozole) and Aromasin (Exemestane). Together, SERMs and AIs make up anti-estrogens. SERMs and Aromatase inhibitors differ on the lines of how they work on matters of estrogen control.

Contrary to common perception that SERMs like Clomid and Nolvadex work by lowering the levels of estrogen, they fill up the receptor sites in breast tissue hence blocking the actions of Estrogen. This way, the Estrogen is prevented from exerting its effect at the site by getting attached to the receptorsite. Additionally, Nolvadex, like other SERMs occupy receptor sites in cells of organs like the liver and act as Estrogens. SERMs do not work by lowering the amountslof Estrogen in plasma. Aromatase inhibitors on the other hand lower the level of Estrogen in plasma by suppressing the secretion of Estrogen through attachment and disabling the enzyme aromatase which is used in converting androgens into Estrogen.

Nolvadex is a non-steroidal SERM which belongs to the family of triphenylethylene which have the effects of both Estrogen antagonistic and Estrogen agonist on the user’s body. This implies that despite having the ability to block the Estrogen effects in the cells of certain tissues, it works to boost the Estrogenic effects in other parts of the body. This has both positive and negative impediments. For instance, in the liver, Nolvadex has Estrogenic effects, which is of benefit as it leads to positive changes in the body cholesterol profiles. Of particular interest is in the breast tissue where Nolvadex where Nolvadex is used as a strong anti-Estrogen.

It is its strong anti-Estrogen effect in breast tissue that makes Nolvadex a medicine where it is used as a first-line therapy in patients with Estrogen-responsive breast cancer. It is also used as a preventive measure in females who are not suffering from breast cancer butat a high risk of contracting the disease as a result of hereditary or other factors. It is this medicinal effect that makes Nolvadex attractive to the athletic and bodybuilding community.

Some of other positive effects of Nolvadex include its ability increase the level of circulation of FSH(Follicle Stimulating Hormone) and LH (Luteinizing Hormone). It is this property that makes it useful in the secretion of Testosterone. This is an example of Nolvadex’s mixed Estrogen agonistic and antagonistic properties where it works by blocking Estrogen’s ability to attach itself to receptors in the hypothalamus. This leads to the changes of the feedback loop of the HPTA hence resulting into increased production of gonadotropins. It is gonadotropins that signals the commencement or increase in the production of Testosterone. It is this property that makes Nolvadex and important element of thePPost Cycle Therapy program. It is especially useful in the weeks after use of anabolic steroid so as to restore and enhance the production of Testosterone.

Typical Testosterone Cycle Post Cycle Therapy

Take a 20 mg Nolvadex pill for 30 days following your cycle.

Take a 50 mg Clomiphene pill for 30 days following your cycle

Take a 1 mg of Anastrozole pill for 20 days following your cycle.

Don’t forget the HCG

All this you can find at napsgear.org

History

Nolvadex was first developed in 1992 by ICI and later launched in the United States. Interestingly, Nolvadex was first used as a medicine in a treatment for female infertility. After several clinical studies however, it was discovered that Nolvadex is very effective in breast cancer treatment. It was finally approved as a breast cancer treatment in by the FDA in 1977. In 1988, it was further approved as a preventive measure for people at high risk of contractingfbreast cancer.

Nolvadex For Gynecomastia

As mentioned earlier, Nolvadex is widely used in the performance enhancement and bodybuilding world as an ancillary help to reducing, combating and preventing Gynecomastia development. This is especially possible when a moderate anabolic steroid is used in a cycle. Nolvadex is used in doses of around 10 – 30mg a day. The common dose used by many people is 20mg Nper day. Using high dosages of Nolvadex beyond 20 – 40mg a day does not lead to any significant effect in reducing gynecomastia.

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The use of Nolvadex in Post Cycle Therapy (PCT)

Another major use of Nolvadex among athletes and bodybuilders is its effectiveness in stimulating the production of Testosterone as shown by many studies. This is achieved through its actions on the hypothalamus and pituitary glands of the brain as well as stimulating the production of Follicle Stimulating Hormone as well as Luteinizing Hormone. These in turn activate the production of Testosterone in the testes. Nolvadex is therefore used during PCT which comes immediately after completion of the anabolic steroid cycle as well as clearance of all anabolic steroids from a person’s system. When used in Post Cycle Therapy (PCT),

 

It is administered in quantities of 20 – 40mg a day for around 4 – 6 weeks. Research has shown that using higher quantities beyond 20 – 40mg a day does not translate to increased Testosterone secretion. Nolvadex is also usually administered together with one or two Testosterone stimulating compounds like an aromatase inhibitor mostly Aromasin or HCG so as to boost its effects on enhancing proper function of HPTA after completing the cycle. Mid-cycle use of Nolvadex cannot counter-act the reduction in use of a anabolic steroid by Testosterone and will not also maintain the secretion of Testosterone together with the use of inhibiting compounds.

It has a very long half-life of around 5 to 7 days and studies have shown that it can be as long as 14 days. As a result, it is not necessary to split and spread dosages across the day.

Typical Testosterone Post Cycle Therapy

Take a 20 mg Nolvadex pill for 30 days following your cycle.

Take a 50 mg Clomiphene pill for 30 days following your cycle

Take a 1 mg of Anastrozole pill for 20 days following your cycle.

Don’t forget the HCG

All this you can find at napsgear.org

Side Effects

Although it is well tolerated by majority of the users, Nolvadex has some side effects to look out for. Due to the difference in Estrogen and androgen proliferation in cells in the body, Nolvadex portrays varying experiences and effects in men and women. This explains the large number of negative side effects of Nolvadex in women compared to men. This is, however, a different narrative when compared to their anabolic steroid use as an ancillary compound.

The official documented side effects of Nolvadex in relation to its use as a breast cancer treatment are vaginal itching, hot flashes, headaches, upset stomach, edema, bone and joint pains and dizziness. To a lesser extent, user may experience pulmonary embolism, deep vein thrombosis, endometrial changes, skin rashes, altered platelet count, changes in white blood cell count and cholesterol changes. These side effects are mainly experienced among female users and to a lesser extend or never experienced among male users. Many people are of the belief that when used together with compounds like Nandrolone or Trenbolone, Nolvadex can increase the sensitivity in these compounds by up-regulating Progesterone receptors. This is not true. On the contrary, it leads to an increase in side effects related to the use of Deca, Trenbolone or any related nor compound.

 

Nolvadex Post Cycle Therapy
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